Our laboratory explores unknown roles of RNA modifications, in particular RNA-linked coenzymes, in biology. Furthermore, we develop methods for imaging and microscopy of RNA in living cells, with a focus on super-resolution techniques. In another research area we develop, characterize and apply photoswitchable biomolecules. We also have a long-standing interest in the origin of life. Our work combines organic synthesis with molecular and cellular biology, biochemistry, bioinformatics and modern bioanalytical methods.