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Here you find a broad overview of our publications in the different research areas and our latest highlights.

Publications: Publikationen


Avidity-based bright and photostable light-up aptamers for single-molecule mRNA imaging

B Bühler, J Schokolowski, A Benderoth, D Englert, F Grün, A Jäschke

Nature Chemical Biology, 1-10 (2023)

A DNA‐based two‐component excitonic switch utilizing high‐performance diarylethenes

SM Büllmann, T Kolmar, NF Zorn, J Zaumseil, A Jäschke

Angewandte Chemie 61 (2022)

A Color‐Shifting Near‐Infrared Fluorescent Aptamer–Fluorophore Module for Live‐Cell RNA Imaging

J Zhang, L Wang, A Jäschke, M Sunbul

Angewandte Chemie 133 (2021)

Super-resolution RNA imaging using a rhodamine-binding aptamer with fast exchange kinetics

M Sunbul, J Lackner, A Martin, D Englert, B Hacene, F Grün, K Nienhaus, A Jäschke

Nature Biotechnology 39 (2021)

Development of High‐Performance Pyrimidine Nucleoside and Oligonucleotide Diarylethene Photoswitches

T Kolmar, SM Büllmann, C Sarter, K Höfer, A Jäschke

Angewandte Chemie 133 (2021)

“Click-switch”–one-step conversion of organic azides into photochromic diarylethenes for the generation of light-controlled systems

S Becht, R Sen, SM Büllmann, A Dreuw, A Jäschke

Chemical Science 12 (2021)

Extensive 5'-Surveillance Guards Against Non-Canonical NAD-Caps of Nuclear mRNAs in Yeast

Yaqing Zhang, David Kuster, Tobias Schmidt, Daniel Kirrmaier, Gabriele Nübel, David Ibberson, Vladimir Benes, Hans Hombauer, Michael Knop, Andres Jäschke

Chemical Science 12 (2020)


Frindert, J., Zhang, Y., Nübel, G., Kahloon, M., Kolmar, L., Hotz-Wagenblatt, A., Burhenne, J., Haefeli, W.E. & Jäschke, A.: Identification, biosynthesis and decapping of NAD-capped RNAs in B. subtilis. Cell Rep. 2018 (24) 1890-1901.

Winz, M.-L., Cahová, H., Nübel, G., Frindert, J., Höfer, K., Jäschke, A.: NAD captureSeq – capturing and sequencing NAD-capped RNA sequences. Nat. Protocols 2017 (12) 122-149.

Höfer, K., Li, S., Abele, F., Frindert, J., Schlotthauer, J., Grawenhoff, J., Du, J., Patel, D.J. & Jäschke, A.: Structure and function of the bacterial decapping enzyme NudC. Nat. Chem. Biol. 2016 (12) 730-734.

Cahová, H., Winz, M.-L., Höfer, K., Nübel, K. & Jäschke, A.: NAD captureSeq suggests NAD as a bacterial cap for a subset of regulatory RNAs. Nature 2015 (519) 374-377.


Wirth, R., Gao, P., Nienhaus, G.U., Sunbul, M. & Jäschke, A.: SiRA: A Silicon Rhodamine-Binding Aptamer for Live-Cell Super-Resolution RNA Imaging. J. Am. Chem. Soc. 2019 (141) 7562-7571.

Sunbul, M.; Jäschke, A., SRB-2: a promiscuous rainbow aptamer for live-cell RNA imaging. Nucleic Acids Res. 2018, 46, gky543.

Sunbul, M. & Jäschke A.: Contact-mediated quenching allows RNA imaging in bacteria with a fluorophore-binding aptamer. Angew. Chem. Int. Ed. 2013 (52) 13401-13404.


Kellis, D.L., Sarter, C., Cannon, B.L., Davis, P.H., Graugnard, E., Lee, J., Kolmar, T., Jäschke, A., Yurke, B. & Knowlton, W.B.: An All-Optical Excitonic Switch Operated in the Liquid and Solid Phases. ACS Nano 2019, 13, 2986–2994.

Cahová, H. & Jäschke, A.: Nucleoside-based diarylethene photoswitches and their facile incorporation into photoswitchable DNA. Angew. Chem. Int. Ed. 2013 (52) 3186-90, Angew. Chem. 2013 (125) 3268-3272.

Singer, M. & Jäschke, A.: Reversibly photoswitchable nucleosides: Synthesis and photochromic properties of diarylethene-functionalized 7-deazaadenosine derivatives, J. Am. Chem. Soc. 2010 (132) 8372–8377.


Ameta, S. & Jäschke, A.: An RNA catalyst that reacts with a mechanistic inhibitor of serine proteases. Chem. Sci. 2013 (4) 957-964.

Serganov, A., Keiper, S., Malinina, L., Tereschko, V., Skripkin, E., Höbartner, C., Polonskaia, A., Phan, A.T. , Wombacher, R., Micura, R., Dauter, Z., Jäschke, A. & Patel, D.J.: Structural basis for Diels-Alder ribozyme catalyzed carbon-carbon bond formation. Nature Struct. Mol. Biol. 2005 (12) 218-224.

Seelig, B., Keiper, S. Stuhlmann, F. & Jäschke, A.: Enantioselective ribozyme catalysis of a bimolecular cycloaddition reaction. Angew. Chem. Int. Ed. 2000 (39) 4576-4579.

Seelig, B. & Jäschke, A.: A small catalytic RNA motif with Diels-Alderase activity. Chem. Biol. 1999 (6) 167-176.


Manz, C., Kobitski, A.Y., Samanta, A., Keller, B.G., Jäschke, A. & Nienhaus, G.U.: Single-molecule study of the full-length riboswitch reveals a multi-stated energy landscape with accelerated dynamics upon ligand binding. Nat. Chem. Biol. 2017 (13) 1172-1178.

Amontov, S. & Jäschke, A.: Controlling the rate of organic reactions: rational design of allosteric Diels-Alderase ribozymes. Nucleic Acids Res. 2006 (34) 5032-5038.

Helm, M., Petermeier, M., Ge, B., Fiammengo, R. & Jäschke, A.: Allosterically activated Diels-Alder catalysis. J. Am. Chem. Soc. 2005 (127) 10492-10493.


Winz, M.-L., Linder, E.C., Becker, J. & Jäschke, A.: Site-specific one-pot triple click labeling for DNA and RNA. Chem. Comm. 2018, 54, 11781-11784.

Krause, A., Hertl, A., Muttach, F. & Jäschke, A.: Phosphine-free Stille-Migita chemistry for the mild and orthogonal modification of DNA and RNA. Chem. Eur. J. 2014 (20) 16613-16619.

Schoch, J., Wiessler, M. & Jäschke, A.: Post-synthetic modification of DNA by inverse electron-demand Diels-Alder reaction, J. Am. Chem. Soc. 2010 (132) 8846–8847.

Seelig, B. & Jäschke, A.: Site-specific modification of enzymatically synthesized RNA: transcription initiation and Diels-Alder reaction, Tetrahedron Lett. 1997 (38) 7729-7732.

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