SELECTED PUBLICATIONS

Here you find a broad overview of our publications in the different research areas and our latest highlights.

 

RECENT PUBLICATIONS

Covalently Functionalized DNA Duplexes and Quadruplexes as Hybrid Catalysts in an Enantioselective Friedel–Crafts Reaction.

S Dey, A Jäschke.  Molecules 25.14 (2020): 3121.

Norbornadiene-bridged diarylethenes and their conversion into turn-off fluorescent photoswitches.

SM Büllmann, A Jäschke - Chemical Communications (Cambridge, England), 2020.

A Novel NAD-RNA Decapping Pathway Discovered by Synthetic Light-Up NAD-RNAs

F Abele, K Höfer, P Bernhard, J Grawenhoff, M Seidel… - Biomolecules, 2020.

The 5′ NAD Cap of RNAIII Modulates Toxin Production in Staphylococcus aureus Isolates

HG Morales-Filloy, Y Zhang, G Nübel, SE George… - Journal of Bacteriology, 2020.

Extensive 5'-Surveillance Guards Against Non-Canonical NAD-Caps of Nuclear mRNAs in Yeast

Y Zhang, D Kuster, T Schmidt, D Kirrmaier, G Nübel… - bioRxiv, 2020.

RhoBAST-a rhodamine-binding aptamer for super-resolution RNA imaging

M Sunbul, J Lackner, A Martin, D Englert, B Hacene… - bioRxiv, 2020

HIGHLIGHTS

Wirth, R., Gao, P., Nienhaus, G.U., Sunbul, M. & Jäschke, A.: SiRA: A Silicon Rhodamine-Binding Aptamer for Live-Cell Super-Resolution RNA Imaging. J. Am. Chem. Soc. 2019 (141) 7562-7571.

Frindert, J., Zhang, Y., Nübel, G., Kahloon, M., Kolmar, L., Hotz-Wagenblatt, A., Burhenne, J., Haefeli, W.E. & Jäschke, A.: Identification, biosynthesis and decapping of NAD-capped RNAs in B. subtilis. Cell Rep. 2018 (24) 1890-1901.

Winz, M.-L., Cahová, H., Nübel, G., Frindert, J., Höfer, K., Jäschke, A.: NAD captureSeq – capturing and sequencing NAD-capped RNA sequences. Nat. Protocols 2017 (12) 122-149.

Manz, C., Kobitski, A.Y., Samanta, A., Keller, B.G., Jäschke, A. & Nienhaus, G.U.*: Single-molecule study of the full-length riboswitch reveals a multi-stated energy landscape with accelerated dynamics upon ligand binding. Nat. Chem. Biol. 2017 (13) 1172-1178.

Höfer, K., Li, S., Abele, F., Frindert, J., Schlotthauer, J., Grawenhoff, J., Du, J., Patel, D.J. & Jäschke, A.: Structure and function of the bacterial decapping enzyme NudC. Nat. Chem. Biol. 2016 (12) 730-734.

Höfer, K. & Jäschke, A.: Molecular biology: A surprise beginning for RNA (News & Views). Nature 2016 (535) 359-360.

Jäschke, A., Höfer, K., Nübel, G. & Frindert, J.: Cap-like structures in bacterial RNA and epitranscriptomic modification. Curr. Opin. Microbiol. 2016 (30) 44-49.

Cahová, H., Winz, M.-L., Höfer, K., Nübel, K. & Jäschke, A.: NAD captureSeq suggests NAD as a bacterial cap for a subset of regulatory RNAs. Nature 2015 (519) 374-377.

NEW RNA MODIFICATIONS IN BIOLOGY

Frindert, J., Zhang, Y., Nübel, G., Kahloon, M., Kolmar, L., Hotz-Wagenblatt, A., Burhenne, J., Haefeli, W.E. & Jäschke, A.: Identification, biosynthesis and decapping of NAD-capped RNAs in B. subtilis. Cell Rep. 2018 (24) 1890-1901.

Winz, M.-L., Cahová, H., Nübel, G., Frindert, J., Höfer, K., Jäschke, A.: NAD captureSeq – capturing and sequencing NAD-capped RNA sequences. Nat. Protocols 2017 (12) 122-149.

Höfer, K., Li, S., Abele, F., Frindert, J., Schlotthauer, J., Grawenhoff, J., Du, J., Patel, D.J. & Jäschke, A.: Structure and function of the bacterial decapping enzyme NudC. Nat. Chem. Biol. 2016 (12) 730-734.

Cahová, H., Winz, M.-L., Höfer, K., Nübel, K. & Jäschke, A.: NAD captureSeq suggests NAD as a bacterial cap for a subset of regulatory RNAs. Nature 2015 (519) 374-377.

RNA IMAGING

Wirth, R., Gao, P., Nienhaus, G.U., Sunbul, M. & Jäschke, A.: SiRA: A Silicon Rhodamine-Binding Aptamer for Live-Cell Super-Resolution RNA Imaging. J. Am. Chem. Soc. 2019 (141) 7562-7571.

Sunbul, M.; Jäschke, A., SRB-2: a promiscuous rainbow aptamer for live-cell RNA imaging. Nucleic Acids Res. 2018, 46, gky543.

Sunbul, M. & Jäschke A.: Contact-mediated quenching allows RNA imaging in bacteria with a fluorophore-binding aptamer. Angew. Chem. Int. Ed. 2013 (52) 13401-13404.

PHOTOSWITCHABLE BIOMOLECULES

Kellis, D.L., Sarter, C., Cannon, B.L., Davis, P.H., Graugnard, E., Lee, J., Kolmar, T., Jäschke, A., Yurke, B. & Knowlton, W.B.: An All-Optical Excitonic Switch Operated in the Liquid and Solid Phases. ACS Nano 2019, 13, 2986–2994.

Cahová, H. & Jäschke, A.: Nucleoside-based diarylethene photoswitches and their facile incorporation into photoswitchable DNA. Angew. Chem. Int. Ed. 2013 (52) 3186-90, Angew. Chem. 2013 (125) 3268-3272.

Singer, M. & Jäschke, A.: Reversibly photoswitchable nucleosides: Synthesis and photochromic properties of diarylethene-functionalized 7-deazaadenosine derivatives, J. Am. Chem. Soc. 2010 (132) 8372–8377.

RIBOZYMES AND SELEX

Ameta, S. & Jäschke, A.: An RNA catalyst that reacts with a mechanistic inhibitor of serine proteases. Chem. Sci. 2013 (4) 957-964.

Serganov, A., Keiper, S., Malinina, L., Tereschko, V., Skripkin, E., Höbartner, C., Polonskaia, A., Phan, A.T. , Wombacher, R., Micura, R., Dauter, Z., Jäschke, A. & Patel, D.J.: Structural basis for Diels-Alder ribozyme catalyzed carbon-carbon bond formation. Nature Struct. Mol. Biol. 2005 (12) 218-224.

Seelig, B., Keiper, S. Stuhlmann, F. & Jäschke, A.: Enantioselective ribozyme catalysis of a bimolecular cycloaddition reaction. Angew. Chem. Int. Ed. 2000 (39) 4576-4579.

Seelig, B. & Jäschke, A.: A small catalytic RNA motif with Diels-Alderase activity. Chem. Biol. 1999 (6) 167-176.

RIBOSWITCHES AND ALLOSTERIC RNAS

Manz, C., Kobitski, A.Y., Samanta, A., Keller, B.G., Jäschke, A. & Nienhaus, G.U.: Single-molecule study of the full-length riboswitch reveals a multi-stated energy landscape with accelerated dynamics upon ligand binding. Nat. Chem. Biol. 2017 (13) 1172-1178.

Amontov, S. & Jäschke, A.: Controlling the rate of organic reactions: rational design of allosteric Diels-Alderase ribozymes. Nucleic Acids Res. 2006 (34) 5032-5038.

Helm, M., Petermeier, M., Ge, B., Fiammengo, R. & Jäschke, A.: Allosterically activated Diels-Alder catalysis. J. Am. Chem. Soc. 2005 (127) 10492-10493.

BIOORTHOGONAL CHEMISTRY

Winz, M.-L., Linder, E.C., Becker, J. & Jäschke, A.: Site-specific one-pot triple click labeling for DNA and RNA. Chem. Comm. 2018, 54, 11781-11784.

Krause, A., Hertl, A., Muttach, F. & Jäschke, A.: Phosphine-free Stille-Migita chemistry for the mild and orthogonal modification of DNA and RNA. Chem. Eur. J. 2014 (20) 16613-16619.

Schoch, J., Wiessler, M. & Jäschke, A.: Post-synthetic modification of DNA by inverse electron-demand Diels-Alder reaction, J. Am. Chem. Soc. 2010 (132) 8846–8847.

Seelig, B. & Jäschke, A.: Site-specific modification of enzymatically synthesized RNA: transcription initiation and Diels-Alder reaction, Tetrahedron Lett. 1997 (38) 7729-7732.

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