Bibliothek

SELECTED PUBLICATIONS

Here you find a broad overview of our publications in the different research areas and our latest highlights.

 

RECENT PUBLICATIONS

Super-resolution RNA imaging using a rhodamine-binding aptamer with fast exchange kinetics.

Sunbul, M., Lackner, J., Martin, A. et al. Nat Biotechnol (2021)


Development of High‐Performance Pyrimidine Nucleoside and Oligonucleotide Diarylethene Photoswitches.

Kolmar, T., Büllmann, S. M., Sarter, C., Höfer, K., & Jäschke, A., Angewandte Chemie International Edition, 2021.

Extensive 5′-surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast.

Y Zhang, D Kuster, T Schmidt, D Kirrmaier, G Nübel… Nat Commun 11, 5508 (2020).

Covalently Functionalized DNA Duplexes and Quadruplexes as Hybrid Catalysts in an Enantioselective Friedel–Crafts Reaction.

S Dey, A Jäschke.  Molecules 25.14 (2020): 3121.

Norbornadiene-bridged diarylethenes and their conversion into turn-off fluorescent photoswitches.

SM Büllmann, A Jäschke - Chemical Communications (Cambridge, England), 2020.

A Novel NAD-RNA Decapping Pathway Discovered by Synthetic Light-Up NAD-RNAs

F Abele, K Höfer, P Bernhard, J Grawenhoff, M Seidel… - Biomolecules, 2020.

The 5′ NAD Cap of RNAIII Modulates Toxin Production in Staphylococcus aureus Isolates

HG Morales-Filloy, Y Zhang, G Nübel, SE George… - Journal of Bacteriology, 2020.

HIGHLIGHTS

Wirth, R., Gao, P., Nienhaus, G.U., Sunbul, M. & Jäschke, A.: SiRA: A Silicon Rhodamine-Binding Aptamer for Live-Cell Super-Resolution RNA Imaging. J. Am. Chem. Soc. 2019 (141) 7562-7571.

Frindert, J., Zhang, Y., Nübel, G., Kahloon, M., Kolmar, L., Hotz-Wagenblatt, A., Burhenne, J., Haefeli, W.E. & Jäschke, A.: Identification, biosynthesis and decapping of NAD-capped RNAs in B. subtilis. Cell Rep. 2018 (24) 1890-1901.

Winz, M.-L., Cahová, H., Nübel, G., Frindert, J., Höfer, K., Jäschke, A.: NAD captureSeq – capturing and sequencing NAD-capped RNA sequences. Nat. Protocols 2017 (12) 122-149.

Manz, C., Kobitski, A.Y., Samanta, A., Keller, B.G., Jäschke, A. & Nienhaus, G.U.*: Single-molecule study of the full-length riboswitch reveals a multi-stated energy landscape with accelerated dynamics upon ligand binding. Nat. Chem. Biol. 2017 (13) 1172-1178.

Höfer, K., Li, S., Abele, F., Frindert, J., Schlotthauer, J., Grawenhoff, J., Du, J., Patel, D.J. & Jäschke, A.: Structure and function of the bacterial decapping enzyme NudC. Nat. Chem. Biol. 2016 (12) 730-734.

Höfer, K. & Jäschke, A.: Molecular biology: A surprise beginning for RNA (News & Views). Nature 2016 (535) 359-360.

Jäschke, A., Höfer, K., Nübel, G. & Frindert, J.: Cap-like structures in bacterial RNA and epitranscriptomic modification. Curr. Opin. Microbiol. 2016 (30) 44-49.

Cahová, H., Winz, M.-L., Höfer, K., Nübel, K. & Jäschke, A.: NAD captureSeq suggests NAD as a bacterial cap for a subset of regulatory RNAs. Nature 2015 (519) 374-377.

NEW RNA MODIFICATIONS IN BIOLOGY

Frindert, J., Zhang, Y., Nübel, G., Kahloon, M., Kolmar, L., Hotz-Wagenblatt, A., Burhenne, J., Haefeli, W.E. & Jäschke, A.: Identification, biosynthesis and decapping of NAD-capped RNAs in B. subtilis. Cell Rep. 2018 (24) 1890-1901.

Winz, M.-L., Cahová, H., Nübel, G., Frindert, J., Höfer, K., Jäschke, A.: NAD captureSeq – capturing and sequencing NAD-capped RNA sequences. Nat. Protocols 2017 (12) 122-149.

Höfer, K., Li, S., Abele, F., Frindert, J., Schlotthauer, J., Grawenhoff, J., Du, J., Patel, D.J. & Jäschke, A.: Structure and function of the bacterial decapping enzyme NudC. Nat. Chem. Biol. 2016 (12) 730-734.

Cahová, H., Winz, M.-L., Höfer, K., Nübel, K. & Jäschke, A.: NAD captureSeq suggests NAD as a bacterial cap for a subset of regulatory RNAs. Nature 2015 (519) 374-377.

RNA IMAGING

Wirth, R., Gao, P., Nienhaus, G.U., Sunbul, M. & Jäschke, A.: SiRA: A Silicon Rhodamine-Binding Aptamer for Live-Cell Super-Resolution RNA Imaging. J. Am. Chem. Soc. 2019 (141) 7562-7571.

Sunbul, M.; Jäschke, A., SRB-2: a promiscuous rainbow aptamer for live-cell RNA imaging. Nucleic Acids Res. 2018, 46, gky543.

Sunbul, M. & Jäschke A.: Contact-mediated quenching allows RNA imaging in bacteria with a fluorophore-binding aptamer. Angew. Chem. Int. Ed. 2013 (52) 13401-13404.

PHOTOSWITCHABLE BIOMOLECULES

Kellis, D.L., Sarter, C., Cannon, B.L., Davis, P.H., Graugnard, E., Lee, J., Kolmar, T., Jäschke, A., Yurke, B. & Knowlton, W.B.: An All-Optical Excitonic Switch Operated in the Liquid and Solid Phases. ACS Nano 2019, 13, 2986–2994.

Cahová, H. & Jäschke, A.: Nucleoside-based diarylethene photoswitches and their facile incorporation into photoswitchable DNA. Angew. Chem. Int. Ed. 2013 (52) 3186-90, Angew. Chem. 2013 (125) 3268-3272.

Singer, M. & Jäschke, A.: Reversibly photoswitchable nucleosides: Synthesis and photochromic properties of diarylethene-functionalized 7-deazaadenosine derivatives, J. Am. Chem. Soc. 2010 (132) 8372–8377.

RIBOZYMES AND SELEX

Ameta, S. & Jäschke, A.: An RNA catalyst that reacts with a mechanistic inhibitor of serine proteases. Chem. Sci. 2013 (4) 957-964.

Serganov, A., Keiper, S., Malinina, L., Tereschko, V., Skripkin, E., Höbartner, C., Polonskaia, A., Phan, A.T. , Wombacher, R., Micura, R., Dauter, Z., Jäschke, A. & Patel, D.J.: Structural basis for Diels-Alder ribozyme catalyzed carbon-carbon bond formation. Nature Struct. Mol. Biol. 2005 (12) 218-224.

Seelig, B., Keiper, S. Stuhlmann, F. & Jäschke, A.: Enantioselective ribozyme catalysis of a bimolecular cycloaddition reaction. Angew. Chem. Int. Ed. 2000 (39) 4576-4579.

Seelig, B. & Jäschke, A.: A small catalytic RNA motif with Diels-Alderase activity. Chem. Biol. 1999 (6) 167-176.

RIBOSWITCHES AND ALLOSTERIC RNAS

Manz, C., Kobitski, A.Y., Samanta, A., Keller, B.G., Jäschke, A. & Nienhaus, G.U.: Single-molecule study of the full-length riboswitch reveals a multi-stated energy landscape with accelerated dynamics upon ligand binding. Nat. Chem. Biol. 2017 (13) 1172-1178.

Amontov, S. & Jäschke, A.: Controlling the rate of organic reactions: rational design of allosteric Diels-Alderase ribozymes. Nucleic Acids Res. 2006 (34) 5032-5038.

Helm, M., Petermeier, M., Ge, B., Fiammengo, R. & Jäschke, A.: Allosterically activated Diels-Alder catalysis. J. Am. Chem. Soc. 2005 (127) 10492-10493.

BIOORTHOGONAL CHEMISTRY

Winz, M.-L., Linder, E.C., Becker, J. & Jäschke, A.: Site-specific one-pot triple click labeling for DNA and RNA. Chem. Comm. 2018, 54, 11781-11784.

Krause, A., Hertl, A., Muttach, F. & Jäschke, A.: Phosphine-free Stille-Migita chemistry for the mild and orthogonal modification of DNA and RNA. Chem. Eur. J. 2014 (20) 16613-16619.

Schoch, J., Wiessler, M. & Jäschke, A.: Post-synthetic modification of DNA by inverse electron-demand Diels-Alder reaction, J. Am. Chem. Soc. 2010 (132) 8846–8847.

Seelig, B. & Jäschke, A.: Site-specific modification of enzymatically synthesized RNA: transcription initiation and Diels-Alder reaction, Tetrahedron Lett. 1997 (38) 7729-7732.

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